Bioinformatics and Genomics

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EGA Team. European Genome-Phenome Archive at the CRG



ATTACHED TEAM LEADER:
Arcadi Navarro
TECHNICIANS:
Mario Alberich, Angel Carreño, Sabela de la Torre, Oscar Martinez, Mauricio Moldes, Jordi Rambla, Marc Sitges

Summary

The EGA is a service for permanent archiving and sharing of all types of personally identifiable genetic and phenotypic data resulting from biomedical research projects. The data at EGA was collected from individuals whose consent agreements authorize data release only for specific research use or to bona fide researchers. Strict protocols govern how information is managed, stored and distributed by the EGA project (view Security Documentation).

Since its launch, researchers from around the world have deposited and accessed data from over 650 studies in the EGA of various types. These studies vary from large-scale array-based genotyping experiments on thousands of samples in case-control designs or population based studies, to sequencing-based studies designed to understand changes in the genome, transcriptome or epigenome in both normal tissue and in various diseases such as cancer. As a result, the EGA has grown from about 50 TB to 1300 TB during the last three years.


Research Projects

  • Secure storage and distribution of human personal identifying data.
  • Analysis of relationships between genomes and phenomes
  • Evolutionary medicine

Selected Publications

Rodriguez JA, Marigorta UM and Navarro A.
“Integrating genomics into evolutionary medicine.”
Curr Op Gen Dev, 29:97–102. doi:10.1016/j.gde.2014.08.009 (2014).

Hartasánchez DA, Vallès-Codina O, Brasó-Vives M, Navarro A.
“Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario.”
G3, 4:1479-89. doi: 10.1534/g3.114.012435 (2014).

Santpere G, Darre F, Blanco S, Alcami A, Villoslada P, Albà MM and Navarro A.
“Genome-wide analysis of wild-type Epstein-Barr virus genomes derived from healthy individuals of the 1000 Genomes Project.”
Genome Biology and Evolution, March 28, 2014. doi:10.1093/gbe/evu. (*)

Faria R and Navarro A.
“Pool and conquer: new tricks for (c)old problems.”
Molecular Ecology, 23:1653–1655. doi:10.1111/mec.12685 (2014).

Olalde I, Allentof ME, Sánchez-Quinto F, Santpere G, Chiang CWK, DeGiorgio M, Prado-Martínez J, Rodríguez JA, Rasmussen S, Quilez J, Ramírez O, Fernández M, Prada ME, Vidal-Encinas JM, Nielsen R, Netea MG, Novembre J, Sturm RA, Sabeti P, Marquès-Bonet T, Navarro A, Willerslev E, Lalueza-Fox C.
“Derived Immune and Ancestral Pigmentation Alleles in a 7,000-Year-old Mesolithic European.”
Nature, 507:225-228 (2014).

(*) External origin