Gene Regulation, Stems Cells and Cancer

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Genome Architecture



GROUP LEADER:
Guillaume Filion
POSTDOCTORAL RESEARCHERS:
Heng-Chang Chen, Olivera Vujatovic
PhD STUDENTS:
Marc Corrales, Ana Catarina Vidinhas De Oliveira, Pol Cusco
TECHNICIAN:
Arantxa Rosado, Victoria Pokusaeva

Summary

We fully understand a mere 3% of the human genome (the coding genome). More challenging is to understand how this tiny fraction is orchestrated by the much larger regulatory genome. What does the regulatory genome consist of? How does it encode information? How is it organized and how does it evolve? Contrary to the coding genome, the information of the regulatory genome is context-dependent. For example, the same promoter can have different levels of activity; the same enhancers can activate one gene or another, depending on available transcription factors and on the local chromatin marks. So the DNA sequence is not enough to understand the function of regulatory sequences. Our research lines focus on the influence of the chromatin context on transcription; and on the co-evolution between the genome and its chromatin context.


Research Projects

  • Developing the TRiP technology
  • Understanding the language of regulatory sequences
  • The chromatin print on the evolution of genomes

Selected Publications

Le Dily F, Baù D, Pohl A, Vicent GP, Serra F, Soronellas D, Castellano G, Wright RH, Ballare C, Filion G, Marti-Renom MA, Beato M.
“Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation.”
Genes Dev., 28(19):2151-62. doi: 10.1101/gad.241422.114 (2014).