Comparative Analysis of Developmental SystemsThis group is part of the EMBL/CRG Research Unit in Systems Biology
- GROUP LEADER:
- Johannes Jaeger
- TECHNICIAN/LAB MANAGER:
- Hilde Janssens
- Damjan Cicin-Sain
- POSTDOCTORAL FELLOWS:
- Anton Crombach, Eva Jiménez-Guri, Bàrbara Negre, Karl Wotton
- INTERPOD FELLOWS:
- Besray Ünal (with Luis Serrano), Juan José Fraire-Zamora (with Jerôme Solon)
- PhD STUDENTS:
- Astrid Hörmann, Berta Verd
- GRADUATE INTERN:
- Helena Roca
- UNDERGRADUATE STUDENTS:
- Anna Alcaine Colet, Núria Bosch, Brenda Gavilán
The diversity of biological form depends on the processes of development and evolution. Our group tries to understand the principles that govern these processes using an interdisciplinary approach based on experimental work and quantitative mathematical modelling of gene regulatory networks. As our experimental system, we study and compare pattern formation during early development of three dipteran insects: the fruit fly (Drosophila melangoaster), a scuttle fly (Megaselia abdita), and a moth midge (Clogmia albipuncata). In 2014, we have published detailed descriptions of embryogenesis in two of these species, and an analysis of gene network models for Clogmia. An equivalent set of models for Megaselia is being reviewed by high-level journals. In parallel, we have developed mathematical methodology required for the detailed comparison of models between species, and have explored the implications of this work for evolutionary theory.
- A quantitative, comparative study of gap gene regulation in dipterans
Karl Wotton, Eva Jiménez-Guri, Anton Crombach, Brenda Gavilán, Núria Bosch, Damjan Cicin-Sain
- Modeling the evolutionary dynamics of the gap gene network
- Phase space analysis of evolving regulatory networks
Berta Verd, Anton Cromlech
- Development of new optimization and model analysis tools (BioPreDyn)
Anton Crombach, Damjan Cicin-Sain
- A systems-level analysis of giant (gt) regulation in Drosophila melanogaster
- A quantitative study of gap gene mutants in Drosophila melanogaster
- Analysis of dorso-ventral patterning in the moth midge Clogmia albipunctata
Eva Jiménez-Guri, Anna Alcaine Colet
- Inferring the thoracic bristle patterning network of Drosophila melanogaster
Bárbara Negre, Helena Roca
- Comparative transcriptomics and genomics of dipteran species
Eva Jiménez-Guri, Karl Wotton, Bárbara Negre (with CRG Genomics/Bioinformatics Core Facilities)
Crombach A, García-Solache M and Jaeger J.
“Evolution of early development in dipterans: reverse-engineering the gap gene network in the moth midge Clogmia albipunctata (Psychodidae).”
BioSystems, 123:75–85 (2014).
Jaeger J and Monk N.
“Bioattractors: dynamical systems theory and the evolution of regulatory processes.”
J Physiol, 592:2267–81 (2014).
Verd B, Crombach A and Jaeger J.
“Classification of transient behaviours in a time-dependent toggle switch model.”
BMC Syst Biol, 8:43 (2014).
Jiménez-Guri E, Wotton KR, Gavilán B and Jaeger J.
“A staging scheme for the development of the moth midge Clogmia albipunctata.”
PLoS ONE, 9:e84422 (2014).
Wotton KR, Jiménez-Guri E, García Matheu B & Jaeger J.
“A staging scheme for the development of the scuttle fly Megaselia abdita.”
PLoS ONE, 9:e84421 (2014).